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Pyran-4-one, 5-hydroxy-2-(hydroxymethyl)

Kojic acid

CAS: 501-30-4

Molecular Formula: C6H6O4

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Pyran-4-one, 5-hydroxy-2-(hydroxymethyl) - Names and Identifiers

Name Kojic acid
Synonyms kojic
Kojic acid
5-Hydroxy-2-hydroxymethyl-4-pyrone
2-HYDROXYMETHYL-5-HYDROXY-4-PYRONE
5-Hydroxy-2-(hydroxymethyl)-γ-pyrone
5-Hydroxy-2-(hydroxymethyl)-4-pyrone
Pyran-4-one, 5-hydroxy-2-(hydroxymethyl)
5-hydroxy-2-(hydroxymethyl)-4h-pyran-4-on
5-Hydroxy-2-(hydroxymethyl)-4H-pyran-4-one
4H-Pyran-4-one,5-hydroxy-2-(hydroxymethyl)-
4H-Pyran-4-one, 5-hydroxy-2-(hydroxymethyl)-
CAS 501-30-4
EINECS 207-922-4
InChI InChI=1/C6H6O4/c7-2-4-1-5(8)6(9)3-10-4/h1,3,7,9H,2H2

Pyran-4-one, 5-hydroxy-2-(hydroxymethyl) - Physico-chemical Properties

Molecular FormulaC6H6O4
Molar Mass142.11
Density1.1712 (rough estimate)
Melting Point152-155 °C (lit.)
Boling Point179.65°C (rough estimate)
Water SolubilitySOLUBLE
Solubility A melanin-specific inhibitor, soluble in water, easily soluble in acetone and ethanol, slightly soluble in ether, ethyl acetate, chloroform and pyridine; insoluble in benzene.
AppearanceYellow brown powder
ColorWhite to beige-brown
Maximum wavelength(λmax)['269nm(CHCl3)(lit.)']
Merck14,5317
BRN120895
pKa7.9(at 25℃)
Storage ConditionStore below +30°C.
StabilityStable. Combustible. Incompatible with strong oxidizing agents.
Refractive Index1.4434 (estimate)
MDLMFCD00006580
Physical and Chemical Properties

dissolved in water, alcohol, acetone, slightly soluble in ether, ethyl acetate, chloroform and pyridine, insoluble in benzene.

melting point 151-156°C

UseFor cosmetics, food additives, pharmaceutical, etc

Pyran-4-one, 5-hydroxy-2-(hydroxymethyl) - Risk and Safety

Hazard SymbolsXn - Harmful
Harmful
Risk CodesR40 - Limited evidence of a carcinogenic effect
R68 - Possible risk of irreversible effects
Safety DescriptionS22 - Do not breathe dust.
S24/25 - Avoid contact with skin and eyes.
S36/37 - Wear suitable protective clothing and gloves.
S36 - Wear suitable protective clothing.
WGK Germany3
RTECSUQ0875000
HS Code29329995

Pyran-4-one, 5-hydroxy-2-(hydroxymethyl) - Upstream Downstream Industry

Raw MaterialsStarch potato

Pyran-4-one, 5-hydroxy-2-(hydroxymethyl) - Reference

Reference
Show more
1. Liu Rong, Sun Weidong, Li Jun committee. Optimization of fermentation medium for kojic acid production from sucrose by Aspergillus oryzae [J]. Light Industry Science and Technology, 2016, 26 (10):5-7.
2. Liu Rong, Sun Weidong, Li Jun committee, etc. Study on fermentation conditions of kojic acid production by Aspergillus oryzae [J]. Guangxi Agricultural Journal, 2016, 06(v.18;No.73):31-35.
3. Tao, Yi, et al. "Magnetic solid-phase extraction coupled with HPLC-Q-TOF-MS for rapid analysis of tyrosinase bins from San-Bai decation by Box-Behnken statistical design." RSC advances 6.111 (2016): 109730-109741.https:// doi.org/10.1039/C6RA22045B
4. [IF = 3.361] Yi Tao et al."Magnetic solid-phase extraction coupled with HPLC-Q-TOF-MS for rapid analysis of tyrosinase binders from San-Bai decoction by Box-Behnken statistical design."Rsc Adv. 2016 Nov;6(111):109730-109741
5. [IF=4.411] Huidan Huang et al."Palladium(II)-Catalyzed Efficient Synthesis of Wedelolactone and Evaluation as Potential Tyrosinase Inhibitor."Molecules. 2019 Jan;24(22):4130
6. [IF=4.329] Lin Song et al."Synthesis, Antimicrobial Moisture Absorption and Retention Activities of Kojic Acid-Grafted Konjac Glucomannan Oligosaccharides."Polymers-Basel. 2019 Dec;11(12):1979
7. [IF=4.952] Yulong Wei et al."Characterization of blueberry (Vaccinium corymbosum L.) catechol oxidases III binding mechanism in response to selected substrates and inhibitors."Lwt Food Sci Technol. 2022 Mar;158:113142
8. [IF=2.281] Zihui Ma et al."Studies on the biosynthetic pathways of melanin in Auricularia auricula."JOURNAL OF BASIC MICROBIOLOGY

Pyran-4-one, 5-hydroxy-2-(hydroxymethyl) - Introduction

It is a melanin-specific inhibitor. After entering the skin cells, it can complex with the copper ions in the cells, change the three-dimensional structure of tyrosinase, prevent the activation of tyrosinase, and inhibit the formation of melanin. It is present in Aspergillus (Aspergillus) medium for wine making. It can be produced by aerobic fermentation of Aspergillus oryzae (Aspergillus oryzae). Used as a reagent for quantitative analysis of ferric iron. Metal chelating agent. Verification of copper and hexavalent uranium. Photometric determination of high iron ions.
Last Update：2022-10-16 17:25:35
Pyran-4-one, 5-hydroxy-2-(hydroxymethyl)
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JIANGSU BSECHEM CHEMICAL TECHNOLOGY CO., LTD.
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Product Name: Kojic acid Request for quotation
CAS: 501-30-4
Tel: +86-17551318830
Email: r@reformchem.com
Mobile: +86-17551318830
QQ: 3787852685 Click to send a QQ messageSend QQ message
Nantong Reform Petro-Chemical CO., LTD.
Spot supply
Product Name: Kojic acid Request for quotation
CAS: 501-30-4
Tel: +86-17551318830
Email: r@reformchem.com­
Mobile: +86-17551318830
QQ: 3785839865 Click to send a QQ messageSend QQ message
Jiangsu Pules Biotechnology Co.,Ltd.
Product Name: Kojic acid Request for quotation
CAS: 501-30-4
Tel: 17505222756
Email: pules.cn@gmail.com
Mobile: +86-17551318830
Wechat: 17505222756
Hefei TNJ Chemical Industry Co.,Ltd.
Product Name: Kojic acid Request for quotation
CAS: 501-30-4
Tel: 0086-551-65418684
Email: sales@tnjchem.com
　　　　 info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840 Click to send a QQ message
Wechat: 0086 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
Wuhan Xingzhongcheng Chemical limited company
Spot supply
Product Name: Kojic acid Request for quotation
CAS: 501-30-4
Tel: 86+027-83389957
Email: 1024042217@qq.com
Mobile: 86+18627766980
QQ: 1024042217 Click to send a QQ message
Wechat: 18627766980
Shanghai Yuanye Bio-Technology Co., Ltd.
Multiple SpecificationsSpot supply
Product Name: Kojic acid Visit Supplier Webpage Request for quotation
CAS: 501-30-4
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409 Click to send a QQ message
Wechat: 18301782025
Bisor Corporation
Product Name: Kojic Acid Request for quotation
CAS: 501-30-4
Tel: 021-61834121
Email: kim@bisorcare.com
Mobile: 13262698927
QQ: 3035159560 Click to send a QQ messageSend QQ message
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Pyran-4-one, 5-hydroxy-2-(hydroxymethyl)
Raw Materials for Pyran-4-one, 5-hydroxy-2-(hydroxymethyl)
Starch potato
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